解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Quantitative neuromuscular monitoring is required to ensure neuromuscular function has recovered completely at the time of tracheal extubation. The TOFscan (Drager Technologies, Canada) is a new three-dimensional acceleromyograph...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002400
更新日期:2018-11-01 00:00:00
abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Hypotension is a risk factor for adverse perioperative outcomes. Machine-learning methods allow large amounts of data for development of robust predictive analytics. The authors hypothesized that machine-learning methods can prov...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002374
更新日期:2018-10-01 00:00:00
abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:Cardiac surgery is associated with cognitive decline and postoperative delirium. The relationship between postoperative delirium and cognitive decline after cardiac surgery is unclear WHAT THIS ARTICLE TELLS US THAT IS NEW:The development of postoperative delirium is associated wi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002253
更新日期:2018-09-01 00:00:00
abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Traumatic brain injury induces cellular proliferation in the hippocampus, which generates new neurons and glial cells during recovery. This process is regulated by N-methyl-D-aspartate-type glutamate receptors, which are inhibite...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002197
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Differentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesiz...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002192
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:We have previously shown that intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury and bupivacaine-induced cardiotoxicity. However, the precise underlying mechanisms are not fully understood. Here we explored the hypothesis that free fatty acid receptor-1 or G-protein-coupled re...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002195
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002229
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The authors hypothesized that low tidal volume (VT) would minimize ventilator-induced lung injury regardless of the degree of mechanical power. The authors investigated the impact of power, obtained by different combinations of VT and respiratory rate (RR), on ventilator-induced lung injury in experimental m...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002143
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The current study used recombinant herpes simplex virus type I to increase expression of µ-opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. It was predicted that viral vector delivery of a combination of genes encoding the µ-opioid recep...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002063
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002138
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Although opioids remain the standard therapy for the treatment of postoperative pain, the prevalence of opioid misuse is rising. The extent to which opioid abuse or dependence affects readmission rates and healthcare utilization is not fully understood. It was hypothesized that surgical patients with a histo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002136
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Acute kidney injury is a common complication after cardiac surgery, leading to increased morbidity and mortality. One suggested cause for acute kidney injury is extracorporeal circulation-induced ischemia-reperfusion injury. In animal studies, cyclosporine has been shown to reduce ischemia-reperfusion injury...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002104
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002103
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Inflammation is a key element in the pathophysiology of cerebral ischemia. This study investigated the role of N-Myc downstream-regulated gene-2 in nuclear transcription factor κB-mediated inflammation in ischemia models. METHODS:Mice (n = 6 to 12) with or without nuclear transcription factor κB inhibitor p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002044
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The discrepancy between predicted effect-site concentration and measured bispectral index is problematic during intravenous anesthesia with target-controlled infusion of propofol and remifentanil. We hypothesized that bispectral index during total intravenous anesthesia would be more accurately predicted by ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001892
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:High-fidelity simulation is known to improve participant learning and behavioral performance. Simulation scenarios generate stress that affects memory retention and may impact future performance. The authors hypothesized that more participants would recall three or more critical key messages at three months ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002045
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001940
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The relative contributions of intraoperative and postoperative hypotension to perioperative morbidity remain unclear. We determined the association between hypotension and a composite of 30-day myocardial infarction and death over three periods: (1) intraoperative, (2) remaining day of surgery, and (3) durin...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0000000000001985
更新日期:2018-02-01 00:00:00
abstract::The use of venovenous extracorporeal membrane oxygenation is increasing worldwide. These patients often require noncardiac surgery. In the perioperative period, preoperative assessment, patient transport, choice of anesthetic type, drug dosing, patient monitoring, and intraoperative and postoperative management of com...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0000000000001887
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not bee...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000001880
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Interscalene block provides optimal shoulder surgery analgesia, but concerns over its associated risks have prompted the search for alternatives. Suprascapular block was recently proposed as an interscalene block alternative, but evidence of its comparative analgesic effect is conflicting. This meta-analysis...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/ALN.0000000000001894
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:We aimed to assess the clinical effectiveness of intravenous exenatide compared to insulin in perioperative blood glucose control in coronary artery bypass grafting surgery patients. METHODS:Patients more than 18 yr old admitted for elective coronary artery bypass grafting were included in a phase II/III no...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000001838
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000001793
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:We compared the effects of etomidate and ketamine on the hypothalamic-pituitary-adrenal axis during sepsis. METHODS:Mice (n = 5/group) were injected intraperitoneally with lipopolysaccharide (10 mg/kg) and 6 h later randomized to receive ketamine (100 mg/kg), etomidate (30 mg/kg), or saline. At two time poi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001704
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Patients with brain injury are at high risk of extubation failure. METHODS:We conducted a prospective observational cohort study in four intensive care units of three university hospitals. The aim of the study was to create a score that could predict extubation success in patients with brain injury. RESULT...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000001725
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. M...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001632
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Optimal analgesia for total knee arthroplasty remains challenging. Many modalities have been used, including peripheral nerve block, periarticular infiltration, and epidural analgesia. However, the relative efficacy of various modalities remains unknown. The authors aimed to quantify and rank order the effic...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/ALN.0000000000001607
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:While electroconvulsive therapy is widely regarded as a lifesaving and safe procedure, evidence regarding its effects on myocardial cell injury is sparse. The objective of this investigation was to determine the incidence and magnitude of new cardiac troponin elevation after electroconvulsive therapy using a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001531
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Conflicting results have been reported concerning the effect of platelet transfusion on several outcomes. The aim of this study was to assess the independent effect of a single early intraoperative platelet transfusion on bleeding and adverse outcomes in cardiac surgery patients. METHODS:For this observatio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001518
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:In 2001, the Centers for Medicare and Medicaid Services issued a rule allowing U.S. states to "opt out" of the regulations requiring physician supervision of nurse anesthetists in an effort to increase access to anesthesia care. Whether "opt out" has successfully achieved this goal remains unknown. METHODS:...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001504
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determ...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000001481
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001470
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The decision to extubate brain-injured patients with residual impaired consciousness holds a high degree of uncertainty of success. The authors developed a pragmatic clinical score predictive of extubation failure in brain-injured patients. METHODS:One hundred and forty brain-injured patients were prospecti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001379
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. METHODS:In this retrospective...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000001310
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:This propensity score-matched cohort study evaluates the effect of anesthetic technique on a 30-day mortality after total hip or knee arthroplasty. METHODS:All patients who had hip or knee arthroplasty between January 1, 2003, and December 31, 2014, were evaluated. The principal exposure was spinal versus g...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001248
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The main cause of unsuccessful peripheral radial artery catheterization using traditional palpation is imprecisely locating the arterial center. The authors evaluated factors causing disparities between the arterial centers determined by palpation versus ultrasound. The authors applied them to create and tes...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000001263
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Crystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model. METHODS:Peritonitis was induced by injectio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001273
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Catheter-related infection is a serious complication of continuous regional anesthesia. The authors tested the hypothesis that single-dose antibiotic prophylaxis is associated with a lower incidence of catheter-related infections. METHODS:Our analysis was based on cases in the 25-center German Network for R...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001218
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Perioperative ischemic optic neuropathy (ION) causes visual loss in spinal fusion. Previous case-control studies are limited by study size and lack of a random sample. The purpose of this study was to study trends in ION incidence in spinal fusion and risk factors in a large nationwide administrative hospita...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001211
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS:The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000001165
更新日期:2016-08-01 00:00:00